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TO-O-1002R
Rare Eye Diseases
TO-O-1002 eye drops, besides its first potential therapeutic use for wet AMD, is currently also in the process of submitting “Orphan Drug Designation (ODD)” for certain type of rare eye diseases (not disclosed) to the US-FDA. By the FDA definition, rare disease is a disease that affects less than 200,000 people in the USa.
Accordingly, some of the known types and incidences of “rare eye diseasesb” are sorted as below:
| Disease | Prevalence | Disease | Prevalence | Disease | Prevalence |
|---|---|---|---|---|---|
| Charles Bonnet syndrome | 500/100,000 | Coloboma | 10/100,000 | Batten disease | 4/100,000 |
| Optic neuritis | 115/100,000 | Neuromyelitis optica | 10/100,000 | Bietti`s crystalline dystrophy | 1.5/100,000 |
| Retinopathy of prematurity | 50/100,000 | Usher syndrome | 7/100,000 | Axenfeld-Rieger syndrome | 1/100,000 |
| Retinitis pigmentosa | 25/100,000 | Leber hereditary optic neuropathy | 7/100,000 | ||
| Stargardt disease | 12/100,000 | Retinoblastoma | 6/100,000 | ||
| Microphthalmia | 10/100,000 | Best disease | 6/100,000 |
a. https://www.fda.gov/patients/rare-diseases-fda
b. https://www.aao.org/eye-health/tips-prevention/20-rare-eye-conditions-that-ophthalmologists-treat
